PROGNOSTIC IMPACT OF REDUCED HER2 PROTEIN EXPRESSION IN POST-NEOADJUVANT THERAPY RESECTION SPECIMENS: A SINGLE INSTITUTION EXPERIENCE AND REVIEW OF THE LITERATURE

Background: Retesting for Human epidermal growth factor receptor-2 (HER2) in post-neoadjuvant therapy resection is variable, and data is conflicting regarding the prognostic significance of changes in HER2 expression pre and post therapy.Methods: We identified 104 patients with localized HER2 IHC 3+ breast cancer who received neoadjuvant trastuzuma

Coral bleaching events have been predicted to occur more frequently in the coming decades with global warming.The susceptibility of corals to bleaching during thermal stress episodes is dependent on many factors and an understanding of these underlying drivers is crucial for conservation management.In 2013, a mild bleaching episode ensued in respon

Abstract Background Healthcare workers suffered with high prevalence of occupational burnout, which might be related with their job satisfaction and well-being.This study aimed to provide evidence of complex interrelations among occupational burnout, flourishing, and job satisfaction, and identify key variables from the perspective of network struc

Ultra-high-frequency (UHF) partial discharge (PD) online monitoring is an effective way to inspect potential faults and insulation defects in power transformers.The construction of UHF PD online monitoring system is a challenge because of the high-frequency and wide-frequency band of the UHF PD signal.This paper presents a novel, intelligent sensor

This issue of our Journal has some special features and innovations.First of all, it is a more capacious issue than usual: it contains two special issues, which we decided to put side by side to ensure that both would be published in an issue in the year 2022.The first is dedicated to the topic of the call that we presented two issues ago on Hybrid